‘Closing the Process’ technology for Cell & Gene Therapy (ATMP), Process Development and R&D. Equipment integration within Grade A(ISO5) isolators for incubation, cell banking, centrifugation, homogenisation steps. Rapid material transfer methodologies. Focus on cell protection and ease of operator manipulation. 

Process:

ProSys’ EOLAS and CORUS isolators are a testament to precision engineering. They support manual, semi-automatic and robotic handling systems, providing versatility to accommodate diverse operational requirements. They can be suitably adapted to allow for a multitude of process equipment integration, including incubators, centrifuges, cooling systems and ancillary devices. Overall assembly H202 de-contamination and / or rapid transfer / cleaning methodologies are employed to achieve desired SAL.

Benefits:

Process Optimisation : Through early engagement with end users, careful technology selection and ‘proof of concept’ studies, ProSys ensures that material handling and operator manipulations are optimised to maintain product quality and production efficiency.

Willingness to Customise : The transfer from ‘open processing’ to working within isolators often requires bespoke design features to achieve desired process and operator outcomes. ProSys brings knowledge, flexibility and a solutions mindset to our end-user discussions in this regard.

Features:

Rapid Transfer Systems : Our integrated ProSgen H202 bio-decontamination system achieves < 20 minutes cycle times for rapid, repeatable material transfer. Rapid transfer ports or equivalent can also be incorporated into isolator design.

Process Equipment Modification : Standard process equipment often needs modification to facilitate integration within closed isolators. ProSys works with our end clients to make the necessary alterations to suit specific requirements.

Compact Footprint : Our EOLAS and CORUS isolators feature ‘All on Board’ technology with easy to access layout for routine maintenance. Our compact design suits small cleanroom footprints with no requirement for external technical space.

Options:

Material ingress studies.

Viral Vector and BSL-2 environment design features.