[fusion_builder_container type=”flex” hundred_percent=”no” hundred_percent_height=”no” hundred_percent_height_scroll=”no” align_content=”stretch” flex_align_items=”flex-start” flex_justify_content=”flex-start” hundred_percent_height_center_content=”yes” equal_height_columns=”no” container_tag=”div” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” status=”published” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”center center” background_repeat=”no-repeat” fade=”no” background_parallax=”none” enable_mobile=”no” parallax_speed=”0.3″ background_blend_mode=”none” video_aspect_ratio=”16:9″ video_loop=”yes” video_mute=”yes” absolute=”off” absolute_devices=”small,medium,large” sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” sticky_transition_offset=”0″ scroll_offset=”0″ animation_direction=”left” animation_speed=”0.3″ filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″][fusion_builder_row][fusion_builder_column type=”1_1″ type=”1_1″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” filter_type=”regular” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ animation_direction=”left” animation_speed=”0.3″ last=”no” border_position=”all” min_height=”” link=””][fusion_imageframe custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” align_medium=”none” align_small=”none” align=”center” hover_type=”none” caption_style=”below” caption_align_medium=”none” caption_align_small=”none” caption_align=”center” caption_title_tag=”5″ animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”3935|full” caption_title=”FIGURE 1″]https://www.prosys.com/wp-content/uploads/2023/04/CASE-STUDY-CONTAINMENT-4.png[/fusion_imageframe][fusion_text rule_style=”default” animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]
The Containment Isolator is designed to, not only, provide a physical barrier between the operator and the product but to also provide a controlled environment, negatively pressurised with an atmospheric condition or a reduced oxygen content using inert gas.
Containment Isolators are necessary throughout a variety of processes, such as, Weighing & Dispensing, Sampling, charging Potent Powders into a vessel and blending of Potent Powders all help to utilise an Isolator. The Isolators can be designed to meet each of your requirements and can take into account, the Containment Performance Targets (CPT), all the way to low nanogram levels.
ProSys has designed and built numerous Isolators for V-blenders, high sheer blenders and IBC blenders. In Figure 1, a small V-blender was integrated inside of an Isolator, due to the small batch size of this very potent powder. This Isolator included two chambers and two RTP’s. Small bulk product containers enter the Isolator via a type 350 RTP System. However, large bulk product containers enter the rear drum, tipping chamber where they are lifted, and tipped into position for connection to the drum port in the rear of the blending chamber.
Upon introduction to the blending chamber, potent powder is weighed into the appropriate quantities and added to the blender. Excipients enter the Isolator system similarly and are weighed and added to the blender. After blending, the powder mixture is discharged from the blender into containers inside the Isolator. Quantities in each container are weighed prior to closure of the containers. Final product containers are cleaned and then exit the blending chamber via the RTP system on the left.
[/fusion_text][fusion_imageframe custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” align_medium=”none” align_small=”none” align=”center” hover_type=”none” caption_style=”below” caption_align_medium=”none” caption_align_small=”none” caption_align=”center” caption_title_tag=”5″ animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”3936|full” caption_title=”FIGURE 2″]https://www.prosys.com/wp-content/uploads/2023/04/CASE-STUDY-CONTAINMENT-5.png[/fusion_imageframe][fusion_text rule_style=”default” animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]Figure 2 illustrates an Isolator integrated with a large V-blender connected via a split butterfly valve (SBV) externally. This two chamber Isolator utilises the chamber on the rear for the introduction of excipient drums, and small quantity API is introduced via RTP’s into the main chamber. Quantities are weighed, ready to be charged into the V-blender docked to the bottom of the main chamber. Material is blended using a post hoist and blended material is metered back into the Isolator via split butterfly valve and dosing valve on the ceiling of main chamber for final packaging.[/fusion_text][fusion_imageframe custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” align_medium=”none” align_small=”none” align=”center” hover_type=”none” caption_style=”below” caption_align_medium=”none” caption_align_small=”none” caption_align=”center” caption_title_tag=”5″ animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”3937|full” caption_title=”FIGURE 3″]https://www.prosys.com/wp-content/uploads/2023/04/CASE-STUDY-CONTAINMENT-6.png[/fusion_imageframe][fusion_text rule_style=”default” animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]Figure 3 demonstrates an Isolator with an internal high sheer blender in the right chamber. Bulk material enters the right chamber. Bulk material enters the right chamber via a split butterfly valve in the ceiling from an IBC and is milled before charging the blender. The middle chamber is used for weighing and the final packaging, while the left chamber is for the removal of it’s final blended powder containers.[/fusion_text][fusion_imageframe custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” align_medium=”none” align_small=”none” align=”center” hover_type=”none” caption_style=”below” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”5″ animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”3938|full” caption_title=”FIGURE 4″]https://www.prosys.com/wp-content/uploads/2023/04/CASE-STUDY-CONTAINMENT-7.png[/fusion_imageframe][fusion_text rule_style=”default” animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]
Figure 4 is a multichambered Isolator for charging an external IBC blender. The left side of the Isolator is used to add API to the IBC and sample from the IBC after blending in nine positions within the IBC. The right side of the Isolator is used for IBC to IBC milling of blended material.
The Isolators will generally feature…
- Spray wand with removable spray gun
- 316L Stainless Steel, fully welded shell construction
– Radius corners and internal edges
– Internal metal surfaces polished 0.5 ~ micron Ra or better
– External metal surfaces polished 0.8 ~ micron RA or better - Toughened double laminate glass door(s) with inflatable seal providing operator access via the glove ports to carry out general tasks and operations inside the Isolator
- Allen Bradley or Siemens PLC and Variable Frequency Drive with 10” HMI
- Local Operator Panel (LOP) with magnehelic gauges, cut-out for weigh scale indicator and E-stop
- Air handling:
– Air entry via a single inlet 99.995% rated H14 Filter mounted in a “safe change” push/push housinG
– Air exits via two 99.995% rated H14 Filters mounted in a “safe change” push/push housing
– Operated with room air via automated open/close valve
– Painted cast aluminium exhaust fan - <75dBa noise level in normal operation
ProSys Technology approaches every project as our customer’s partner, to assist them in producing an Isolator System that it the best solution for their process and operators. Get in touch today to find out more!
[/fusion_text][fusion_global id=”3925″][fusion_global id=”4776″][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]
